Fluxoteine

U.S. Brand Names: Prozac®,

Use: Fluxoteine is a selective serotonin reuptake inhibitor. This drug affects chemicals in the brain that may become unbalanced. It is used to treat depression and the physical and mental symptoms of premenstrual dysphoric disorder.

Pregnancy Risk Factor and Implications: Category C, it is not known if this drug harms the fetus so consult a doctor before using it if you are pregnant. Fluxoteine passes into breast milk and may affect the nursing infant so consult with a doctor before using if you are nursing.

Contraindications: Do not use fluxoteine if you have used a MAOI during the last 2 weeks. Serious and sometimes fatal reactions have occurred when these medicines have been used together. Do not take fluxoteine if you are taking thioridazine (Mellaril) since dangerous and even fatal irregular heartbeats may occur when these medicines are taken together. You must wait 5 weeks after stopping fluxetine before taking thioridazine. Tell your doctor if you have liver disease, kidney disease, diabetes, if you suffer from seizures or if you suffer from mania or have suicidal thoughts since these conditions may affect whether or not he prescribes fluxoteine.

Warnings/Precautions: Use caution when driving, operating machinery, or performing other hazardous activities since this drug may cause dizziness or drowsiness. Use alcohol with caution since alcohol may increase this drowsiness or dizziness.

Adverse Reactions: Fluxoteine may cause an allergic reaction, an irregular heartbeat or pulse, low blood pressure (dizziness, weakness), high blood pressure (severe headache, blurred vision), chills or fever, unusual bleeding or bruising, a rash or hives, headache, tremor, nervousness, anxiety, difficulty concentrating, nausea, diarrhea, dry mouth, changes in appetite or weight, weakness, increased sweating, sleepiness or insomnia, or decreased sex drive, impotence, or difficulty having an orgasm.

Overdose/Toxicology: In case of an overdose seek emergency medical attention. Symptoms of an overdose may include nausea, vomiting, tremor, agitation, seizures, drowsiness, hyperactivity, and enlarged pupils.

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Sertraline

U.S. Brand Names: Zoloft®

Use: Sertraline is a selective serotonin reuptake inhibitors which affects chemicals in your brain that may become unbalanced. This drug is used to treat depression.

Pregnancy Risk Factor and Implications: Category C, it is unknown if sertraline harms the fetus so consult a doctor before using this drug if you are pregnant. It is also unknown whether sertraline enters breast milk so consult a doctor if you are nursing a baby.

Contraindications: Do not use sertraline if you have used a MAOI during the last 2 weeks as serious, sometimes fatal reactions have occurred when these medicines have been used together. Consult with your doctor if you have liver disease, kidney disease, suffer from seizures, or suffer from mania or have suicidal thoughts before using this drug.

Warnings/Precautions: Use caution when driving, operating machinery, or performing other hazardous activities as this drug may cause drowsiness or dizziness. Use alcohol with caution as it may increase this drowsiness and dizziness.

Adverse Reactions: Side effects of sertraline include an allergic reaction, an irregular heartbeat or pulse, low blood pressure (dizziness, weakness), high blood pressure (severe headache, blurred vision), chills or fever, headache, tremor, nervousness, anxiety, nausea, diarrhea, dry mouth, changes in appetite or weight, sleepiness or insomnia, decreased sex drive, impotence, and difficulty having an orgasm.

Overdose/Toxicology: If you overdose on sertraline seek emergency medical attention. Symptoms of an overdose include nausea, vomiting, tremor, seizures, agitation, drowsiness, hyperactivity, and enlarged pupils.

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Paroxetine

U.S. Brand Names: Paxil® Paxil CR®

Use: Paroxetine is a selective serotonin reuptake inhibitor that affects chemicals in the brain that may become unbalanced. This drug is used to treat depression and various anxiety disorders.

Pregnancy Risk Factor and Implications: Category C, it is not known if paroxetine harms the fetus so consult a doctor before using it if you are pregnant. This drug passes into breast milk so do not take it without consulting a doctor if you are nursing a baby.

Contraindications: Do not use paroxetine if you have used a MAOI during the last two weeks as serious and sometimes fatal reactions have occurred when these medicines have been used together. Do not take this drug if you are taking thioridazine (Mellaril) as dangerous even fatal irregular heartbeats may occur if these medicines are taken together. You must wait for five weeks after stopping paroxetine before taking thioridazine. Before taking paroxetine tell your doctor if you have liver disease, kidney disease, suffer from seizures, or suffer from mania or have suicidal thoughts.

Warnings/Precautions: Use caution when driving, operating machinery, or performing other hazardous activities, may cause dizziness or drowsiness. Use alcohol with caution since it may increase drowsiness or dizziness.

Adverse Reactions: Paroxetine may cause an allergic reaction, an irregular heartbeat or pulse, low blood pressure (dizziness, weakness), high blood pressure (severe headache, blurred vision), unusual bleeding or bruising, fever or chills, headache, tremor, nervousness, anxiety, nausea, diarrhea, dry mouth, or changes in appetite or weight, sleepiness or insomnia, decreased sex drive, impotence, and difficulty having an orgasm.

Overdose/Toxicology: If you overdose on this drug seek emergency medical attention. Symptoms of an overdose include nausea, vomiting, tremor, seizures, agitation, drowsiness, hyperactivity, and enlarged pupils.

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Clomipramine

Nutrients Depleted: Coenzyme Q10, Vitamin B12

U.S. Brand Names: Anafranil®

Use: This drug is used to treat obsessive-compulsive disorder and may also relieve depression, panic attacks, and chronic pain.

Pregnancy Risk Factor and Implications: Category C; this drug enters breast milk, do not breast fed while using this drug.

Contraindications: Do not use if you are in the acute recovery stage of recent myocardial infarction or if you have used an MAOI within the last 14 days.

Warnings/Precautions: Seizures are likely and are dose-related; use with caution in patients with asthma, bladder outlet destruction and narrow-angle glaucoma.

Adverse Reactions:

Greater than 10% experience:

• Central Nervous System: Dizziness, drowsiness, headache
  
• Gastrointestinal: Constipation, increased appetite, nausea, unpleasant taste, weight gain
  
• Neuromuscular & skeletal: Weakness
  
  

1% to 10% experience:

• Cardiovascular: Arrhythmias, hypotension
  
• Central Nervous System: Confusion, delirium, hallucinations, nervousness, restlessness, parkinsonian syndrome, insomnia
  
• Gastrointestinal: Diarrhea, heartburn
  
• Genitourinary: Dysuria, sexual dysfunction
  
• Neuromuscular & skeletal: Fine muscle tremors
  
• Ocular: Blurred vision, eye pain
  
• Miscellaneous: Diaphoresis (excessive)
  
  

Less than 1% experience: Anxiety, seizures, alopecia, photosensitivity, breast enlargement, glactorrhea, SIADH, trouble with gums, decreased lower esophageal sphincter tone may cause GE reflux, testicular edema, agranulocytosis, leukopenia, eosinophilia, cholestatic jaundice, increased liver enzymes, increased intraocular pressure, tinnitus, allergic reactions

Overdose/Toxicology: Symptoms of overdose include agitation, confusion, hallucinations, urinary retention, hypothermia, hypotension, tachycardia, ventricular tachycardia, seizures, and coma. Following initiation of essential overdose management, toxic symptoms should be treated.

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Alprazolam

U.S. Brand Names: Xanax®

Use: Alprazolam affects chemicals in the brain that may become unbalanced and cause anxiety. This drug is used in the treatment of anxiety, nervousness, anxiety disorder related tension, and panic disorders.

Pregnancy Risk Factor and Implications: Category D. Alprazolam is known to harm the fetus; do not take this drug without consulting a doctor if you are pregnant. It is unknown whether or not Alprazolam enters breast milk; consult with a doctor if you are nursing.

Contraindications: Do not take this drug if you have narrow-angle glaucoma as this drug may worsen the condition. Consult with your doctor if you have kidney disease, liver disease, asthma, bronchitis, emphysema, or another respiratory disease, or if you are depressed or have suicidal thoughts.

Warnings/Precautions: Use caution when driving, operating machinery, or performing other hazardous activities as this drug may cause drowsiness and/or dizziness. Use alcohol with caution as it may increase this drowsiness and dizziness. Do not stop taking this drug suddenly if you have been taking it for several weeks as this will cause withdrawal symptoms and discomfort. Avoid other sedatives, sleeping pills, and tranquilizers. Only use them if your doctor approves. If you are over 60 you are more likely to experience side effects. This drug if not approved for use with children under 18. Please not that: Dangerous sedation, dizziness, or drowsiness may occur if alprazolam is taken with any of the medicines listed above; seizure medications may not be as effective when you are taking alprazolam (tell your doctor if you have a seizure disorder); the effects of blood pressure medications may be increased, and very low blood pressure may result (be alert for signs of low blood pressure (weakness, dizziness, fatigue) and talk to your doctor about your medication).

Adverse Reactions: Side effects to this drug may include an allergic reaction, sores in the mouth or throat, yellowing of the skin or eyes, a rash, hallucinations or severe confusion, changes in vision, drowsiness, dizziness, clumsiness, depression, nausea, vomiting, diarrhea, constipation, difficulty urinating, vivid dreams, headache, dry mouth, decreased sex drive, and changes in behavior.

Overdose/Toxicology: Symptoms of an overdose include sleepiness, dizziness, confusion, a slow heart beat, difficulty breathing, difficulty walking and talking, an appearance of being drunk, and unconsciousness. In the case of an overdose seek emergency medical attention immediately.

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Busprione

U.S. Brand Names: Buspar®

Use: Busprione affects chemicals in the brain that may become unbalanced and cause anxiety. It is used to reduce the fear, tension, and anxiety associated with anxiety disorders.

Pregnancy Risk Factor and Implications: Category B; consult with your doctor before taking this drug if you are pregnant. Busprione passes into the breast milk and may affect the nursing infant; do not take this drug without consulting your doctor if you are nursing.

Contraindications: Do not take Busprione if you have had a previous allergic reaction to this drug or to any of its components. Do not this drug if you have taken a MAOI during the last 2 weeks. Inform your doctor if you have kidney disease, liver disease, or a history of alcohol or drug addiction before using this drug. Do not use in children younger than 18.

Warnings/Precautions: When beginning treatment with this drug use caution when driving, operating machinery, or performing other hazardous activities as Busprione may cause drowsiness or dizziness. Use with caution with alcohol as alcohol consumption may increase drowsiness and dizziness when interacting with Busprione. This drug may increase the effects of other drugs that cause drowsiness (antidepressants, antihistamines, sedatives that are used to treat insomnia, pain relievers, anxiety medicines, and muscle relaxants). Grapefruit and grapefruit juice may interact with this drug and could lead to adverse effects. Also tell your doctor if you are taking Nefazodone (Serzone), Itraconazole (Sporanox), Erythromycin (E-Mycin, E.E.S., Ery-Tab, Eryc, others), or selegiline (Eldepryl) before using Busprione.

Adverse Reactions: Side effects may include an allergic reaction, chest pain or an irregular heartbeat, headache, dizziness, lightheadedness, slurred speech, confusion, or blurred vision, numbness or tingling in your hands, feet, arms, or legs, depression, uncontrollable movements of your arms, legs, tongue, or lips, drowsiness or fatigue, dry mouth, and an increase in nightmares or dreams.

Overdose/Toxicology: Symptoms of an overdose include drowsiness, very deep sleep, nausea, vomiting, and unusually small pupils. In the event of an overdose seek emergency medical attention immediately.

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Leuprolide

U.S. Brand Names: Lupron®, Lupron Depot®, Lupron Depot-Ped® (leuprolide acetate)

Use: Leuprolide is related to the naturally occurring hormone gonadotropin-releasing hormone (GnRH). This hormone is responsible for the release of the hormones testosterone and estrogen in the body. Leuprolide is used to reduce the amount of these two hormones in the body. For treating PMS leuprolide suppresses ovulation.

Pregnancy Risk Factor and Implications: Category X; Do not use this drug while pregnant as it will cause birth defects in an unborn baby. It is unknown if this drug passes into breast milk; consult with your doctor before using if you are nursing.

Contraindications: Inform your doctor of any serious illness you have before using this drug. Do not use this drug is you are pregnant. Do not use if your are allergic to leuprolide or to any of its ingredients or if you have undiagnosed abnormal vaginal bleeding.

Warnings/Precautions: Patients with metastatic vertebral lesions and/or with urinary tract obstruction should be closely observed during the first few weeks of therapy. Leuprolide acetate treatment suppresses the pituitary-gonadal system. In female patients menstruation should stop with effective doses of Lupron Depot, if regular menstruation persists past the second month the patient should notify her doctor. Since this drug may cause a small loss in bone density, some of which is not reversible, treatment beyond six months is not recommended for patients with major risk factors for bone loss such as chronic alcohol or tobacco use, a family history of osteoporosis, chronic use of drugs that reduce bone mass (anticonvulsants, corticosteroids).

Adverse Reactions: (For Lupron Depot)

5% or more:

• Cardiovascular: Edema
  
• Gastrointestinal: Nausea/vomiting
  
• Endocrine: Decreased testicular size, hot flashes/sweats, impotence
  
• Central/Peripheral Nervous System: General pain
  
• Respiratory: Dyspnea
  
• Miscellaneous: Asthenia
  
  

Less than 5%:

• Cardiovascular System: Angina, Cardiac arrhythmia
  
• Gastrointestinal System: Anorexia, Diarrhea
  
• Endocrine System: Gynecomastia, Libido decrease
  
• Musculoskeletal System: Bone pain, Myalgia
  
• Central/Peripheral Nervous System: Paresthesia, Insomnia
  
• Respiratory System: Hemoptysis
  
• Integumentary System: Dermatitis, Local skin reactions, Hair growth
  
• Urogenital System: Dysuria, Frequency/urgency, Hematuria, Testicular pain
  
• Miscellaneous: Diabetes, Fever/chills, Hard nodule in throat, Increased calcium, Weight gain, Increased uric acid
  
  

Additional side effects:

• Cardiovascular System: Congestive heart failure, ECG changes/ischemia, High blood pressure, Hypotension, Myocardial infarction, Murmur, Phlebitis/thrombosis, Pulmonary emboli, Transient ischemic attack/stroke
  
• Gastrointestinal System: Constipation, Dysphagia, Gastrointestinal bleeding, Gastrointestinal disturbance, Hepatic dysfunction, Peptic ulcer, Rectal polyps
  
• Endocrine System: Breast tenderness or pain, Libido increase, Thyroid enlargement
  
• Hemic and Lymphatic System: Anemia, Decreased WBC
  
• Musculoskeletal System: Ankylosing spondylosis, Joint pain, Pelvic fibrosis
  
• Central/Peripheral Nervous System: Anxiety, Blurred vision, Dizziness/light-headedness, Headache, Hearing disorder, Sleep disorders, Lethargy, Memory disorder, Mood swings, Nervousness, Numbness,
  
• Peripheral neuropathy, Spinal fracture/paralysis, Syncope/blackouts, Taste disorders
  
• Respiratory System: Cough, Pleural rub, Pneumonia, Pulmonary fibrosis, Pulmonary infiltrate, Respiratory disorders, Sinus congestion Integumentary System: Carcinoma of the skin/ear, Dr. skin, Ecchymosis, Hair loss, Itching, Pigmentation, Skin lesions
  
• Urogenital System: Bladder spasms, Incontinence, Penile swelling, Prostrate pain, Urinary obstruction, Urinary tract infection
  
• Miscellaneous: Depression, Hypoglycemia, Hypoproteinemia, Increased BUN, Increased creatinine, Infection/inflammation, Ophthalmologic disorders, Swelling (temporal bone)

Overdose/Toxicology: Symptoms of an overdose are unknown but may include decreased activity, difficulty breathing, and irritation at the injection site. If an overdose is suspected seek emergency medical attention or call your doctor.

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Danazol

U.S. Brand Names: Danocrine®

Use: Used to treat pain and/or infertility due to endometriosis, fibrocystic breast disease, and hereditary angioedema.

Warnings/Precautions: Consult with your doctor if you have had a past allergic reaction to danazol, androgens (male hormones) or to anabolic steroids. This drug may may cause male-like changes in female children and cause premature sexual development in male children. It may also slow or stop growth in any child. In older adults this drug may increase the risk of developing prostate enlargement or cancer in older males. Inform your doctor if you are taking anticoagulants or Tacrolimus (Prograf) since Danazol may increase the effects of these drugs. Also tell your doctor if you have blood clotting disorders, severe liver disease, a tumor caused by too much male hormones or a tumor on the genitals, unusual bleeding from the vagina, porphyria, diabetes mellitus, epilepsy, heart disease, kidney disease, and migraine headaches. Check in frequently with your doctor to make sure that this medicine does not cause unwanted effects. For example, if you are a female check with your doctor if you develop a larger clitoris, if your voice deepens, or if you experience unnatural hair growth. In patients with diabetes, consult with your doctor if you notice a change in the results of your blood or urine glucose test. Danazol may cause your skin to become more sensitive in the sunlight so take precautions when going outside. While you are on Danazol the female menstrual period may be irregular or nonexistent; if it does not return within 60 to 90 days after stopping the drug, consult a doctor. Do not use hormone-containing birth control methods while on this drug.

Adverse Reactions:

Males and Females: Acne; dark-colored urine; increased oiliness of hair or skin; muscle cramps or spasms; swelling of feet or lower legs; unusual tiredness or weakness; weight gain (rapid), bleeding gums; bloating, pain or tenderness of abdomen or stomach; blood in urine; burning, numbness, pain, or tingling in all fingers except the smallest finger; changes in vision; chest pain; chills; complete or partial numbness or weakness on one side of body; cough; coughing up blood; diarrhea; difficulty in speaking; difficulty in swallowing; discharge from nipple; eye pain; fast heartbeat; fever; headache; hives or other skin rash; joint pain; light-colored stools; loss of appetite (continuing); loss of muscle coordination; more frequent nosebleeds; muscle aches; nausea; purple- or red-colored, or other spots on body or inside the mouth or nose; restlessness; shortness of breath; sore throat; sweating; tingling, numbness, or weakness in legs, which may move upward to arms, trunk, or face; unusual bruising or bleeding; unusual tiredness, weakness, or general feeling of illness; vomiting; yellow eyes or skin, flushing or redness of skin; mood or mental changes; nervousness, increased sensitivity of skin to sunlight.

Females only: Decrease in breast size; irregular menstrual periods; weight gain, burning, dryness, or itching of vagina; vaginal bleeding, enlarged clitoris; hoarseness or deepening of voice; unnatural hair growth.