Various studies have reported on vitamin C as well as other
antioxidant vitamins and their effects on blood vessels.
In a study conducted by German researchers and published in the
American Heart Association's (AHA) journal
"Circulation" on July 1, 1996, the researchers found
that vitamin C helps to absorb some of the damaging chemicals
(called free radicals) in cigarette smoke that cause damage to
the arterial wall.
The researchers compared blood flow in the arms of 10 healthy
male non-smokers and 10 male chronic smokers. They found that the
blood vessels in chronic smokers were more constricted. When a
chemical was added to their blood to relax and widen the vessels,
the response was limited. However, when vitamin C was injected
into the same artery, it greatly improved the dilation effect.
The scientists suggest that vitamin C helps improve the ability
of the thin layer of cells in the artery called the endothelium
to function properly (i.e., either narrow or widen). They further
note that vitamin C may protect against biochemical changes in
LDL cholesterol (the "bad cholesterol) that cause it to be
deposited in artery walls (a process called atherosclerosis).
In two other studies, reported at the annual AHA scientific
sessions in New Orleans on November 12, 1996, researchers studied
the effects of vitamins C and E on arteries. The first study, led
by Dr. Henry Ting of Brigham and Women's Hospital in Boston,
measured blood flow in 12 people with normal cholesterol
(averaging 180 mg/dl) and 12 people with high cholesterol
(averaging 280 mg/dl). The researchers took blood-flow
measurements before and after injecting vitamin C into the artery
in the forearm. They found that vitamin C improved the blood flow
and widened blood vessels in the people with high cholesterol but
had no effect on the people with normal cholesterol levels.
In another study led by Dr. Gary Plotnick at the University of
Maryland Medical center in Baltimore, the researchers gave 20
adults with normal cholesterol levels (between 133 and 200 mg/dl)
a 900 calorie meal that was at least 50% saturated fat. They then
took timed blood flow measurements using a device that
temporarily halted blood flow in order to see the extent the
artery relaxed and widened to allow blood to flow. They found
that after 4 hours, the subjects' arteries had only widened by
8%, half of what was expected by the researchers. However, as
they predicted, when the subjects took vitamins E and C with
their meals, the blood vessels widened by 18% after the four hour
period.
The scientists believe that these antioxidant vitamins may help
treat the effects of a high fat diet. However, the reader should
note that these researchers have not conclusively determined the
benefits of antioxidant vitamins and the AHA does not recommend
the use of antioxidant vitamin supplements until more information
is known.
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